The vagus nerve is made up of an intricate neural network that maintains homeostasis and equilibrium in important processes as well as interfacing with inflammatory, autonomic, mood and pain regulation. Learn how we are utilising the neuromodulatory effects of the vagus nerve to improve patient outcomes and increase quality of life.

Heart
Brain

Approach

​

AF
HF

Atrial

Fibrillation ​

 

TREAT AF II: A Randomised Clinical Trial

ONGOING

 

BRIDGE AF: A Randomised Clinical Trial

ONGOING

 

TREAT AF (Transcutaneous Electrical Vagus Nerve Stimulation to Suppress Atrial Fibrillation): A Randomised Clinical Trial

Stavrakis et al. Clinical Electrophysiology 2020

 

 

 

​

Heart

Failure ​

 

TREAT-HF Low Level Tragus Stimulation in Acute Decompensated Heart Failure: A Randomized Clinical Trial 

Ongoing 

 

TRANSFER HF: A Randomized Clinical Trial Ongoing 

Ongoing 

 

TECO-HF (Neuromodulation of Inflammation and Vascular Function in Systolic Heart Failure): A Randomized Clinical Trial 

Ongoing 

 

Neuromodulation to Treat Patients With Heart Failure With Preserved Ejection Fraction

Stavrakis et al. J Am Heart Assoc 2022

 

Effects of low-level tragus stimulation on endothelial function in heart failure with reduced ejection fraction

Dasari et al. Journal of Cardiac Failure 2021

 

 

 

 

​

N

Neuro

 

 

Non-Invasive vagal nerve stimulation in autonomic disorders

Ongoing

  

Non-Invasive vagal nerve stimulation in Long Covid syndrome

Expected 2022

 

Vagus Nerve Stimulation as a Treatment of Long Covid

Expected 2022

 

Transcutaneous Auricular Vagus Nerve Stimulation (tVNS) can Reverse the Manifestations of the Long-COVID Syndrome: A Pilot Study

Verbanck et al. Frontiers in Neurology and Neuroscience 2021

  

Ne

Neuro-

enhancement

 

Improvement of memory-based reading recall using transcutaneous auricular vagus nerve stimulation     

Thakkar et al. 2021 

 

The effects of taVNS on novel language learning in young adults 

Thakkar et al. 2020

 

The effect of transcutaneous auricular vagus nerve stimulation on reading comprehension 

Richardson et al. 2020

 

 

 

 

Ex

Science of Modulating the Nervous System​

 ​

Experimental

 

 

Transcutaneous vagal nerve stimulation synergizes with radiotherapy by ameliorating the anti-tumor response in lung cancer     

Completed

 

Effects of non-invasive vagal nerve stimulation on radiation-induced inflammation and cancer prognosis     

Reijmen et al. 2020 

 

+ >20 Stealth Studies